Lothian Hypertension and Lipid clinics

Adherence testing

In some cases it may be useful to check for adherence to the existing drug regimen, particularly when there has been no apparent response to 3 or more drugs.

This investigation should only be requested after: 

  • Persisting hypertension is confirmed by ABPM.
  • The patient is on a 4-drug regimen, (including at least 1 diuretic). 


Adherence testing is arranged through the cardiovascular risk clinic via SCI gateway referral as per guidance on Refhelp.


List of drugs that can be tested for: 


ACE inhibitor

Enalapril, Lisinopril, Perindopril, Quinapril, Ramipril, Trandolapril

Angiotensin-Receptor blockers

Candesartan, Irbesartan, Losartan, Olmesartan, Valsartan

Calcium channel blockers

Amlodipine, Diltiazem, Felodipine, Lacidipine, Lercanidipine, Nifedipine, Verapamil


Thiazide/thiazide-like: Bendroflumethiazide, Chlortalidone, Hydrochlorothiazide, Indapamide

K+-sparing: Amiloride, Eplerenone, Spironolactone

Loop: Furosemide, Bumetanide

Beta-adrenoceptor blockers

Atenolol, Bisoprolol, Labetalol, Metoprolol

Alpha-adrenoceptor blockers


Centrally-acting drugs

Methyldopa, Minoxidil, Moxonidine


Aliskiren, Hydralazine